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In the Pomplun Lab we develop technologies for the discovery of novel chemical modalities that can address challenging drug targets. We create innovative drug discovery platforms based on rational design and on combinatorial chemistry to ultimately identify hit compounds targeting therapeutically relevant biomolecules. Towards this goal we use and develop modern organic synthesis procedures, bioconjugation methodologies, individual and combinatorial solid phase synthesis, tandem mass spectrometry and we develop ultrahigh throughput screening techniques.