Peer reviewed publications 2015 – 2021

Jurgen M. Kolos,+ Sebastian Pomplun,+ Sascha Jung, Benedikt Rieß, Patrick L. Purder, Andreas M. Voll,  Stephanie Merz, Monika Gnatzy, Thomas M. Geiger, Ingrid Quist-Løkken, Jerome Jatzlau, Petra Knaus, Toril Holien,  Andreas Bracher, Christian Meyners, Paul Czodrowski, Vera Krewald  and Felix Hausch; Picomolar FKBP inhibitors enabled by a single water-displacing methyl group in bicyclic [4.3.1] aza-amides; Chem. Sci., 2021,; Part of the 2021 Chemical Science HOT Article Collection; (+ = equal contribution)

Sebastian Pomplun,+ Muhammad Jbara,+ Carly Schissel,Ann Boija, Susanne Wilson Hawken, Isaac Klein, and Bradley L. Pentelute; Parallel automated flow synthesis of covalent protein complexes that inhibit MYC-driven transcription; ACS Central Science, 2021, 7, 8, 1408–1418 (+ these authors contributed equally; article highlighted as supplementary cover);

Cover Art by S. Pomplun

Muhammad Jbara,+ Sebastian Pomplun,+ Carly Schissel,Susanne Wilson Hawken, Jacob Rodrigues, Ann Boija, Isaac Klein, Stephen L. Buchwald and Bradley L. Pentelute; Engineering of bioactive transcription factors via flow synthesis and palladium crosscoupling; JACS, 2021, 143, 30, 11788–11798 (+ these authors contributed equally);

Sebastian Pomplun, Muhammad Jbara, Anthony J. Quartararo, Genwei Zhang,Joseph Brown, Yen-Chun Lee, Xiyun Ye, Stephanie Hanna and Bradley L. Pentelute; De Novo Discovery of High Affinity Peptide Binders for the SARS-CoV-2 Spike Protein; ACS Central Science, 2021, 7, 1, 156–163;

Sebastian Pomplun*; Targeting the SARS-CoV-2-spike protein: from antibodies to miniproteins and peptides; RSC Med. Chem, 2020, (invited publication for a themed ‘Emerging Investigators’ issue), (*corresponding author)

Sebastian Pomplun, Zachary P. Gates, Genwei Zhang, Anthony J. Quartararo, and Bradley L. Pentelute; Discovery of nucleic acid binding molecules from combinatorial biohybrid nucleobase peptide libraries; JACS, 2020, 2020, 142, 46, 19642–19651, (highlighted as front cover on Dec 9th 2020),

Cover Art by S. Pomplun & M. Vater

Sebastian Pomplun+, Christopher Shugrue+, Adeline Schmitt, Carly Schissel, Charlotte Farquhar, Bradley L. Pentelute; Secondary Amino Alcohols: Traceless Cleavable Linkers for Use in Affinity Capture and Release; Angew. Chem. Int. Ed. 2020, 59, 11566–11572, (+ these authors contributed equally);

Sebastian Pomplun*, Mohamed YH Mohamed, Tobias Oelschlaegel, Christian Wellner, Frank Bergmann; Efficient Pictet Spengler Bioconjugation with N-Substituted Pyrrolyl Alanine Derivatives; Angew. Chem. Int. Ed., 2019, 58 (11), 3542; (*corresponding author);

Sebastian Pomplun, Claudia Sippel, Andreas Hähle, Donald Tay, Kensuke Shima, Alina Klages, Can Murat Ünal, Benedikt Rieß, Hui Ting Toh, Guido Hansen, Ho Sup Yoon, Andreas Bracher, Peter Preiser, Jan Rupp, Michael Steinert and Felix Hausch;Chemogenomic profiling of human and microbial FK506-binding proteins; J. Med. Chem., 2018; 61 (8), pp 3660–3673;

Xixi Feng, Sebastian Pomplun, Felix Hausch; Recent progress in FKBP ligand development; Curr. Mol. Pharm., 2016, 1, 27 -36

Sebastian Pomplun+, Y. Wang+, A. Kirschner, C. Kozany, A. Bracher, F. Hausch; Rational Design and Asymmetric Synthesis of Potent and Neurotrophic Ligands for FK506-Binding Proteins (FKBPs); Ang. Chem. Int. Ed., 2015, 54 (1), 345, (+ these authors contributed equally);

Serena Cuboni, Christian Devigny, Bastiaan Hoogeland, Andrea Strasser, Sebastian Pomplun, Barbara Hauger, Georg Höfner, Klaus T. Wanner, Matthias Eder, Armin Buschauer, Florian Holsboer, and Felix Hausch; Loratadine and Analogues: Discovery and Preliminary Structure-Activity Relationship of Inhibitors of the Amino Acid Transporter B(0)AT2; J. Med. Chem., 2014, 57 (22), 9473


[GRANTED] Sebastian Pomplun, Yansong Wang, Matthias Bischoff, Felix Hausch; Diazabicyclo[4.3.1]decane derivatives for treatment of psychiatric disorders; EP3097103B1, US9914732B2

[PUBLISHED – PENDING] Sebastian Pomplun, Tobias Oelschlaegel, Frank Bergmann; A method for labelling aldehyde containing target molecules; Patent Pub. No. WO2018189214A1

[PUBLISHED – PENDING] Sebastian Pomplun, Simon Loibl, Frank Bergmann; Cleavable linker for peptide synthesis; WO2020030663A1

[PUBLISHED – PENDING] Sebastian Pomplun, Hannes Kuchelmeister, Christian Wellner, Frank Bergmann, Ian Chau, Peter Crisalli, Hannah Kallewaard-Lum, Hasham Saqib; A method for sequencing reaction with tagged nucleoside obtained via pictet spengler reaction; WO2018191389A1

[PUBLISHED – PENDING] Sebastian Pomplun, Frank Bergmann; HPLC free purification of peptides by the use of new capping reagents; WO2020144111A1