ERC Proof of Concept grant ExSELence for the PomplunLab!!!
ERC Proof of Concept grant MYSTIC for the PomplunLab!!!
https://www.universiteitleiden.nl/en/news/2025/02/from-research-to-practice-leiden-researchers-awarded-european-grant
https://onlinelibrary.wiley.com/doi/10.1002/anie.202416082
DuoMYC paper out in Angewandte. Read now in open access!
Congratulations to Brecht, Jan, Damiano and Cherina!
Poster Price for Miguel at the EMBO Chemical Biology
Congratulations 🙂
Open Competition Science-M
Pept(o)Body: Precision Chemistry to Control Nanoparticle Size, Shape and Surface Functionality
Matthias Barz & Sebastian Pomplun (Leiden Academic Centre for Drug Research)
The combination of advanced solid phase peptide synthesis and controlled living polymerisation methods enables the Pept(o)Body project to develop monodisperse synthetic nanoparticles, in which size, shape and spatial arrangement of surface functionality can be controlled with molecular precision. This novel methodology provides access to fully synthetic antibody mimetics bearing the ground-breaking potential to reduce the costs of immune therapies, make them broadly available or establish the next generation of antibody-drug conjugates with superior therapeutic efficacy.
November 2023
Very excited to join the Oncode Institute with the Pomplun Lab and help outsmarting cancer with novel chemical modalities:
Oncode Institute News
https://oncodeinstitute.nl/news/oncode-institute-expands-with-ten-talented-junior-investigators
Leiden University News
https://www.universiteitleiden.nl/en/news/2023/11/sebastian-pomplun-joins-oncode-institute
Miguel’s master thesis in our lab was awarded the prize for the best master thesis in bioengineering!!!
April 2023
Poster prize for Miguel at the Dutch Peptide Symposium.
Congratulations!
March 2023
Auguri a Damiano Arella!
After his Erasmus stay in our Lab, Damiano successfully defended his thesis at the University of Parma!
Thesis title: Engineering synthetic transcription factors to inhibit the oncoprotein Myc
Jan 2023
Master students learning about Novel Chemical Modalities in Drug Discovery ( ASOs, ADCs, PROTACs, peptides, Display technologies DELs,…). Very fun course 🙂
December 2022
See our comment by Hermen Overkleeft and Sebastian on the click chemistry Nobel price and Bertozzi’s participation in our LED3 seminar series. (https://www.universiteitleiden.nl/en/science/led3/led3-lectures)
December 2022
Group picture!!! 🙂
November 2023
NWO M1 grant for the pomplunlab! Starting February 2023 we will work on a combinatorial discovery platform for covalent ligands.
November 2023
Miguel defended his Master Thesis entitled “Targeting the “undruggable”: a combinatorial platform for the discovery of covalent peptide inhibitors of protein-protein interactions”, obtaining the final mark of 20/20 at the Instituto Tecnico Lisboa in Biomedical Engineering.
Nice conclusion of his ERASMUS internship in our lab. Big congratulations! And we are looking forward to have Miguel back as a PhD student from February!
October 2023
Our new Master Students Cherina and Benthe started working in the lab. A lot of fun with novel MYC inhibitors and combinatorial synthesis 🙂
Lotte joined for a summer internship. Having fun with both synthetic and recombinant protein preparation.
Check out Sebastian’s perspective on affinity selection methodologies for ultra-rapid drug discovery
(in German ;-))
https://onlinelibrary.wiley.com/doi/10.1002/nadc.20224126035
Sebastian’s ERC-2021-Starting grant SynTra has officially started in June 2022! We very much look forward to creating synthetic transcription factors to tune and control gene expression in disease.
Welcome to 4 Bachelor (BOO) students in our lab!
Benthe, Paula, Samba and Mick will be working on inhibiting the oncogenic transcription factor MYC.
Poster prize for Edith at the LACDR Spring Symposium,
in April 2022.
Congratulations!!!
Pomplun Lab 