Publications
Mike Filius et al.
Generative Design of High-Affinity Peptides Using BindCraft
https://pubs.acs.org/doi/10.1021/acschembio.5c00774
Highlighted in: https://www.science.org/content/blog-post/cheap-computation-small-peptide-binders
Edith van der Nol, Nils A. Haupt, et al.
Barcode-free hit discovery from massive libraries enabled by automated small molecule structure annotation
https://www.nature.com/articles/s41467-025-65282-1
Highlighted in:
https://www.science.org/content/blog-post/screening-without-tagging
Brecht Ellenbroek et al.,
AlphaFold-Guided Discovery of an Overlapping MYC/Miz-1 Interface Enables Peptidomimetic Disruption of MYC/MAX
https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.202500740
Brecht D. Ellenbroek‡, Dr. Jan Pascal Kahler‡, Damiano Arella, Cherina Lin, Dr. Willem Jespers, Eliane Ann-Katrin Züger, Dr. Micha Drukker, Dr. Sebastian J. Pomplun*
Development of DuoMYC: a synthetic cell penetrant miniprotein that efficiently inhibits the oncogenic transcription factor MYC
Brecht D. Ellenbroek+, Jan Pascal Kahler+, Sophie R. Evers, and Sebastian J. Pomplun*;
Synthetic Peptides: Promising Modalities for the Targeting of
Disease-Related Nucleic Acids
https://doi.org/10.1002/anie.202401704
(+ = equal contribution)
J. Miguel Mata,+ Edith van der Nol,+ and Sebastian J. Pomplun*;
Advances in Ultrahigh Throughput Hit Discovery with Tandem Mass Spectrometry Encoded Libraries;
JACS, 2023, https://doi.org/10.1021/jacs.3c04899; (+ = equal contribution)
Publications from Postdoc and PhD
Anna Charalampidou, Thomas Nehls, Christian Meyners, Satish Gandhesiri, Sebastian Pomplun, Bradley L. Pentelute, Frederik Lermyte, and Felix Hausch*; Automated Flow Peptide Synthesis Enables Engineering of Proteins with Stabilized Transient Binding Pockets; ACS Central Science; 2024, https://doi.org/10.1021/acscentsci.3c01283
Jurgen M. Kolos,+ Sebastian Pomplun,+ Sascha Jung, Benedikt Rieß, Patrick L. Purder, Andreas M. Voll, Stephanie Merz, Monika Gnatzy, Thomas M. Geiger, Ingrid Quist-Løkken, Jerome Jatzlau, Petra Knaus, Toril Holien, Andreas Bracher, Christian Meyners, Paul Czodrowski, Vera Krewald and Felix Hausch; Picomolar FKBP inhibitors enabled by a single water-displacing methyl group in bicyclic [4.3.1] aza-amides; Chem. Sci., 2021, https://doi.org/10.1039/D1SC04638A; Part of the 2021 Chemical Science HOT Article Collection; (+ = equal contribution)
Sebastian Pomplun,+ Muhammad Jbara,+ Carly Schissel,Ann Boija, Susanne Wilson Hawken, Isaac Klein, and Bradley L. Pentelute; Parallel automated flow synthesis of covalent protein complexes that inhibit MYC-driven transcription; ACS Central Science, 2021, 7, 8, 1408–1418 (+ these authors contributed equally; article highlighted as supplementary cover); https://doi.org/10.1021/acscentsci.1c00663
Muhammad Jbara,+ Sebastian Pomplun,+ Carly Schissel,Susanne Wilson Hawken, Jacob Rodrigues, Ann Boija, Isaac Klein, Stephen L. Buchwald and Bradley L. Pentelute; Engineering of bioactive transcription factors via flow synthesis and palladium crosscoupling; JACS, 2021, 143, 30, 11788–11798 (+ these authors contributed equally); https://doi.org/10.1021/jacs.1c05666
Sebastian Pomplun, Muhammad Jbara, Anthony J. Quartararo, Genwei Zhang,Joseph Brown, Yen-Chun Lee, Xiyun Ye, Stephanie Hanna and Bradley L. Pentelute; De Novo Discovery of High Affinity Peptide Binders for the SARS-CoV-2 Spike Protein; ACS Central Science, 2021, 7, 1, 156–163; https://doi.org/10.1021/acscentsci.0c01309
Sebastian Pomplun*; Targeting the SARS-CoV-2-spike protein: from antibodies to miniproteins and peptides; RSC Med. Chem, 2020, (invited publication for a themed ‘Emerging Investigators’ issue), doi.org/10.1039/D0MD00385A (*corresponding author)
Sebastian Pomplun, Zachary P. Gates, Genwei Zhang, Anthony J. Quartararo, and Bradley L. Pentelute; Discovery of nucleic acid binding molecules from combinatorial biohybrid nucleobase peptide libraries; JACS, 2020, 2020, 142, 46, 19642–19651, (highlighted as front cover on Dec 9th 2020), https://doi.org/10.1021/jacs.0c08964
Sebastian Pomplun+, Christopher Shugrue+, Adeline Schmitt, Carly Schissel, Charlotte Farquhar, Bradley L. Pentelute; Secondary Amino Alcohols: Traceless Cleavable Linkers for Use in Affinity Capture and Release; Angew. Chem. Int. Ed. 2020, 59, 11566–11572, (+ these authors contributed equally); https://doi.org/10.1002/anie.202003478
Sebastian Pomplun*, Mohamed YH Mohamed, Tobias Oelschlaegel, Christian Wellner, Frank Bergmann; Efficient Pictet Spengler Bioconjugation with N-Substituted Pyrrolyl Alanine Derivatives; Angew. Chem. Int. Ed., 2019, 58 (11), 3542; (*corresponding author); https://doi.org/10.1002/anie.201814200
Sebastian Pomplun, Claudia Sippel, Andreas Hähle, Donald Tay, Kensuke Shima, Alina Klages, Can Murat Ünal, Benedikt Rieß, Hui Ting Toh, Guido Hansen, Ho Sup Yoon, Andreas Bracher, Peter Preiser, Jan Rupp, Michael Steinert and Felix Hausch;Chemogenomic profiling of human and microbial FK506-binding proteins; J. Med. Chem., 2018; 61 (8), pp 3660–3673; https://doi.org/10.1021/acs.jmedchem.8b00137
Xixi Feng, Sebastian Pomplun, Felix Hausch; Recent progress in FKBP ligand development; Curr. Mol. Pharm., 2016, 1, 27 -36
Sebastian Pomplun+, Y. Wang+, A. Kirschner, C. Kozany, A. Bracher, F. Hausch; Rational Design and Asymmetric Synthesis of Potent and Neurotrophic Ligands for FK506-Binding Proteins (FKBPs); Ang. Chem. Int. Ed., 2015, 54 (1), 345, (+ these authors contributed equally); https://doi.org/10.1002/anie.201408776
Serena Cuboni, Christian Devigny, Bastiaan Hoogeland, Andrea Strasser, Sebastian Pomplun, Barbara Hauger, Georg Höfner, Klaus T. Wanner, Matthias Eder, Armin Buschauer, Florian Holsboer, and Felix Hausch; Loratadine and Analogues: Discovery and Preliminary Structure-Activity Relationship of Inhibitors of the Amino Acid Transporter B(0)AT2; J. Med. Chem., 2014, 57 (22), 9473
Pomplun Lab 